Prescription stimulant misuse and diversion is an increasing issue of public health and ethical concern, but not often addressed by clinicians. Individuals who abuse stimulants may achieve a “high” via parenteral routes and individuals also misuse psychostimulants to increase academic performance. Short-acting formulations of stimulants have a much greater risk for misuse and diversion compared to long-acting stimulants due to their pharmacokinetic profile and easy crushability. All clinicians involved the prescribing of stimulants need to be alert to the signs of abuse, diversion, and misuse.