St. John's Wort (SJW) (Hypericum perforatum) is a plant used as a herbal medicine for many centuries in the treatment of mood disorders. The active ingredient is thought to be from hypericin/hyperforin and other flavonoids.
Substrate of (Metabolized by) | |
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Induces | 3A4 (potent!)[1] |
Inhibits |
Starting | 300 mg TID (or 450 mg BID) |
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Titration | Plasma levels gradually rise over several weeks |
Maximum | 1800 mg |
Taper |