Perimenopausal Depression (also known as Major Depressive Disorder with peripartum onset in the DSM-5) is a subtype of depression experienced by women during the perimenopausal period, defined as the interval when a women’s menstrual cycles become irregular, usually between ages of 45 and 49.
1st line | Monotherapy: Desvenlafaxine, cognitive behavioural therapy |
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2nd line | Monotherapy or Adjunctive therapy: Transdermal estradiol* (level 2) Monotherapy: Citalopram, duloxetine, escitalopram, mirtazapine, quetiapine XR, venlafaxine XR (level 3) Monotherapy: Omega-3, fluoxetine, nortriptyline, paroxetine, sertraline (level 4) |
3rd line | Monotherapy: Mindfulness-based CBT, supportive psychotherapy (level 4) |