Major Neurocognitive Disorder

Criterion A

Evidence of significant cognitive decline from a previous level of performance in one or more cognitive domains (complex attention, executive function, learning and memory, language, perceptual-motor, or social cognition) based on:

  1. Concern of the individual, a knowledgeable informant, or the clinician that there has been a significant decline in cognitive function; and
  2. A substantial impairment in cognitive performance, preferably documented by standardized neuropsychological testing or, in its absence, another quantified clinical assessment.

Criterion B

The cognitive deficits interfere with independence in everyday activities (i.e., at a minimum, requiring assistance with complex instrumental activities of daily living such as paying bills or managing medications).

Criterion C

The cognitive deficits do not occur exclusively in the context of a delirium.

Criterion D

The cognitive deficits are not better explained by another mental disorder (e.g., major depressive disorder, schizophrenia).

  • Major or Mild Neurocognitive Disorder Due to Alzheimer’s Disease
  • Major or Mild Frontotemporal Neurocognitive Disorder
  • Major or Mild Neurocognitive Disorder With Lewy Bodies
  • Major or Mild Vascular Neurocognitive Disorder
  • Substance/Medication-Induced Major or Mild Neurocognitive Disorder
  • Major or Mild Neurocognitive Disorder Due to HIV Infection
  • Major or Mild Neurocognitive Disorder Due to Prion Disease
  • Major or Mild Neurocognitive Disorder Due to Parkinson’s Disease
  • Major or Mild Neurocognitive Disorder Due to Huntington’s Disease
  • Major or Mild Neurocognitive Disorder Due to Another Medical Condition
  • Major or Mild Neurocognitive Disorder Due to Multiple Etiologies
  • Unspecified Neurocognitive Disorder