Hashimoto's Encephalopathy (HE) (also known as Steroid Responsive Encephalopathy Associated with Autoimmune Thyroiditis [SREAT]), is a rare, clinically heterogeneous neurological disorder associated with Hashimoto's disease and positive thyroid autoantibodies. It is is a form of autoimmune encephalitis. It is increasingly recognized as an important and treatable cause of autoimmune encephalitis, though remains somewhat controversial as a diagnosis.
Diagnosis can be made when all 6
of the following criteria have been met (Graus et al. 2016):[1]
Patients with a non-specific encephalopathy with subclinical or overt thyroid disease, anti-thyroid antibodies, and no other explanation for the symptoms should be considered for a trial of steroids. Most patients treated with corticosteroids with or without levothyroxine will have clinical improvement.[2]