Bleeding risks (e.g. - GI bleeding and intracranial bleeding) are associated with selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) in individuals with risk factors. This risk is primarily due the effect of SSRIs inhibiting serotonin uptake in platelets.
High affinity | Clomipramine, fluoxetine, sertraline, and paroxetine |
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Intermediate affinity | Citalopram, fluvoxamine, and venlafaxine |
Low affinity | Doxepin, mirtazapine, moclobemide, and nortriptyline[14] |