The Psychology of Psychopharmacology plays a huge role on patient and provider expectations of medications. This goes beyond the placebo effect, and there is strong evidence that shows psychological and interpersonal factors have a significant effect in psychopharmacology.[1] The pill, the patient, the prescriber, and the partnership all play a role in pharmacotherapy response and non-response. The therapeutic alliance in the doctor-patient relationship also has a significant impact on outcomes too.[2]