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addictions:alcohol [2020/07/18 23:32]
psychdb
addictions:alcohol [2020/07/18 23:40] (current)
psychdb
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 ==== Liver Function ==== ==== Liver Function ====
-<alert icon="​fa fa-arrow-circle-right fa-lg fa-fw" type="​success">​See ​main article: **[[meds:​benzos:​home|]]**</​alert>​+<alert icon="​fa fa-arrow-circle-right fa-lg fa-fw" type="​success">​See ​also article: **[[meds:​benzos:​home|]]**</​alert>​
 One may want to switch patients to lorazepam instead if blood work shows //​significantly//​ elevated liver enzymes or if there are signs of acute liver failure (e.g. - jaundice). One may want to switch patients to lorazepam instead if blood work shows //​significantly//​ elevated liver enzymes or if there are signs of acute liver failure (e.g. - jaundice).
  
 <callout type="​question"​ title="​Diazepam or Lorazepam?"​ icon="​true">​ <callout type="​question"​ title="​Diazepam or Lorazepam?"​ icon="​true">​
-The ''​LOT''​ benzodiazpines (''​L''​orazepam,​ ''​O''​xazepam,​ and ''​T''​amazepam are less reliant ​on +The ''​LOT''​ benzodiazpines (''​L''​orazepam,​ ''​O''​xazepam,​ and ''​T''​amazepam are metabolized via glucuronidation (Phase II metabolism),​ which is less dependent ​on global liver function. Thus, these benzodiazepines can be used in individuals with severe liver impairment.
 \\ \\ \\ \\
   * **[[meds:​benzos:​1-diazepam|Diazepam]]** has a long half-life, multiple active metabolites,​ and should only be used in healthy patients with no signs of liver disease.   * **[[meds:​benzos:​1-diazepam|Diazepam]]** has a long half-life, multiple active metabolites,​ and should only be used in healthy patients with no signs of liver disease.