- Last edited on April 30, 2020
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| - | ====== Cannabis Use Disorder ====== | ||
| - | {{INLINETOC}} | ||
| - | ===== Primer ===== | ||
| - | **Cannabis Use Disorder** is a substance use disorder characterized by a problematic pattern of cannabis (marijuana) use leading to clinically significant impairment or distress. Like with all substance use disorders, there is a complex interplay between biological, social, psychological, and cultural factors. | ||
| - | ===== Cannabis ===== | ||
| - | Cannabis (marijuana) is a genus of flowering plant in the family Cannabaceae. ∆9-tetrahydrocannabinol (THC) is the principal psychoactive constituent of cannabis. | ||
| - | |||
| - | == Street names == | ||
| - | Pot, weed, herb, ganga | ||
| - | == Effects == | ||
| - | Euphoria, dry-mouth, dilated pupils, giddiness, hunger, anti-nausea, paranoia, cognitive impairment | ||
| - | == Routes == | ||
| - | Smoked, oral | ||
| - | |||
| - | ==== Mechanism of Action ==== | ||
| - | * ∆9-tetrahydrocannabinol | ||
| - | * Agonists at cannabinoid receptors CB1, CB2: GPCR | ||
| - | * CNS, peripheral and immune system expression | ||
| - | |||
| - | == Cost == | ||
| - | $40 per 1/8 ounce | ||
| - | |||
| - | |||
| - | ===== Psychosis ===== | ||
| - | The link between cannabis use and psychosis is controversial. However, there is increasing evidence to suggest a link between cannabis use and it's effect on accelerating the onset of schizophrenia in vulnerable individuals. This is especially true with cannabis use during puberty.[([[https://www.scientificamerican.com/article/link-between-adolescent-pot-smoking-and-psychosis-strengthens/|Scientific American: Link between Adolescent Pot Smoking and Psychosis Strengthens | ||
| - | (2017)]])] Whether it is a true cause-and-effect remains under investigation. | ||
| - | |||
| - | ===== Treatment ===== | ||
| - | Focus on psychosocial management over medical treatment | ||
| - | |||
| - | ===== Resources ===== | ||
| - | |||
| - | <WRAP group> | ||
| - | <WRAP quarter column> | ||
| - | ==== For Patients ==== | ||
| - | * [[https://medicine.utoronto.ca/news/what-we-know-and-dont-know-about-health-effects-recreational-cannabis|What We Know – and Don't Know – About the Health Effects of Recreational Cannabis]] | ||
| - | * {{ :addictions:lower-risk_cannabis_use_guidelines_brochure_v2.pdf |Canada’s Lower-Risk Cannabis Use Guidelines (Patients)}} | ||
| - | </WRAP> | ||
| - | |||
| - | <WRAP quarter column> | ||
| - | ==== For Providers ==== | ||
| - | * {{ :addictions:lower-risk_cannabis_use_guidelines_evidence_brief.pdf |Canada’s Lower-Risk Cannabis Use Guidelines (Providers)}} | ||
| - | * [[https://www.porticonetwork.ca/web/podcasts/quick-takes/cannabis-oct2018|What all physicians need to know about cannabis legalization]] | ||
| - | * [[http://crismontario.ca/research-projects/lower-risk-cannabis-use-guidelines|Canada Lower Risk Cannabis Use Guidelines]] | ||
| - | * [[http://www.cfp.ca/content/64/2/111|Simplified Guideline for Prescribing Medical Cannabinoids in Primary Care]] | ||
| - | </WRAP> | ||
| - | <WRAP quarter column> | ||
| - | == Articles == | ||
| - | * [[https://www.youtube.com/watch?v=vt2sFO-QPpg|Miley Cyrus Reveals Her Reasons for Quitting Weed]] | ||
| - | </WRAP> | ||
| - | <WRAP quarter column> | ||
| - | == Research == | ||
| - | * [[https://www.nature.com/articles/s41598-017-11645-8|Renard J et al. Adolescent THC Exposure Causes Enduring Prefrontal Cortical Disruption of GABAergic Inhibition and Dysregulation of Sub-Cortical Dopamine Function. Sci Rep. 2017 Sep 12;7(1):11420.]] | ||
| - | </WRAP> | ||
| - | </WRAP> | ||