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Last edited on January 25, 2022

This shows you the differences between two versions of the page.

--- addictions:home [on April 25, 2020]
psychdb
+++ addictions:home [on September 8, 2020]
psychdb [Biology of Addiction]
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 <WRAP half column>
 ===== Addiction Medicine Topics =====
-<catlist addictions: -columns:3 -noHead -noAddPageButton -sortAscending -noNSInBold>
+<catlist addictions: -columns:1 -noHead -noAddPageButton -sortAscending -noNSInBold>
 </WRAP>
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 ===== Biology of Addiction =====
+The nucleus accumbens is a major input structure of the basal ganglia and integrates information from cortical and limbic structures to mediate goal-directed behaviors.[([[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931870/|Scofield, M. D., Heinsbroek, J. A., Gipson, C. D., Kupchik, Y. M., Spencer, S., Smith, A. C., Roberts-Wolfe, D., & Kalivas, P. W. (2016). The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis. Pharmacological reviews, 68(3), 816–871.]])] The relative activity of dopamine and serotonin in the nucleus accumbens plays a major part in the development of behavioural addiction and substance use disorders. Dopamine promotes wanting and serotonin satiation. All drugs of addiction have been shown to raise dopamine levels and lower serotonin levels in the NA.
   * [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099425/|Casey, B. J., & Jones, R. M. (2010). Neurobiology of the adolescent brain and behavior: implications for substance use disorders. Journal of the American Academy of Child & Adolescent Psychiatry, 49(12), 1189-1201.]]