- Last edited on January 11, 2024
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anxiety:gad [on May 16, 2019] |
anxiety:gad [on May 16, 2019] |
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| ==== Medications ==== | ==== Medications ==== | ||
| <panel type="info" title="Pharmacotherapy for generalized anxiety disorder" no-body="true" footer="CR = controlled release; XL = extended release; XR = extended release. *Note: Each of these 2nd-line treatments have distinct mechanisms, efficacy and safety profiles. Benzodiazepines would be considered first in most cases, except where there is a risk of substance abuse. Bupropion XL should be reserved for later. Quetiapine XR remains a good choice in terms of efficacy, but given the metabolic concerns associated with atypical antipsychotic, it should be reserved for patients who cannot be provided antidepressants or benzodiazepines."> | <panel type="info" title="Pharmacotherapy for generalized anxiety disorder" no-body="true" footer="CR = controlled release; XL = extended release; XR = extended release. *Note: Each of these 2nd-line treatments have distinct mechanisms, efficacy and safety profiles. Benzodiazepines would be considered first in most cases, except where there is a risk of substance abuse. Bupropion XL should be reserved for later. Quetiapine XR remains a good choice in terms of efficacy, but given the metabolic concerns associated with atypical antipsychotic, it should be reserved for patients who cannot be provided antidepressants or benzodiazepines."> | ||
| - | ^ 1st line | Agomelatine, [[meds:snri:duloxetine|duloxetine]], [[meds:antidepressants:ssri:escitalopram|escitalopram]], [[meds:antidepressants:ssri:paroxetine|paroxetine]], [[meds:antidepressants:ssri:paroxetine|paroxetine CR]], [[meds:mood-stabilizers-anticonvulsants:pregabalin|pregabalin]], [[meds:antidepressants:ssri:sertraline|sertraline]], [[meds:snri:venlafaxine|venlafaxine XR]] | | + | ^ 1st line | Agomelatine, [[meds:antidepressants:snri:duloxetine|duloxetine]], [[meds:antidepressants:ssri:escitalopram|escitalopram]], [[meds:antidepressants:ssri:paroxetine|paroxetine]], [[meds:antidepressants:ssri:paroxetine|paroxetine CR]], [[meds:mood-stabilizers-anticonvulsants:pregabalin|pregabalin]], [[meds:antidepressants:ssri:sertraline|sertraline]], [[meds:antidepressants:snri:venlafaxine|venlafaxine XR]] | |
| ^ 2nd line | Alprazolam*, bromazepam*, bupropion XL*, buspirone, diazepam*, [[meds:non-benzo-anxiolytics:hydroxyzine|hydroxyzine]], imipramine, lorazepam*, quetiapine XR*, vortioxetine | | ^ 2nd line | Alprazolam*, bromazepam*, bupropion XL*, buspirone, diazepam*, [[meds:non-benzo-anxiolytics:hydroxyzine|hydroxyzine]], imipramine, lorazepam*, quetiapine XR*, vortioxetine | | ||
| ^ 3rd line | Citalopram, divalproex chrono, fluoxetine, mirtazapine, trazodone | | ^ 3rd line | Citalopram, divalproex chrono, fluoxetine, mirtazapine, trazodone | | ||