- Last edited on February 1, 2024
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cl:1-delirium [on February 1, 2024] psychdb [Pharmacological] |
cl:1-delirium [on February 1, 2024] psychdb [Pharmacological] |
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| Don't forget to order a baseline ECG for a [[meds:qtc|QTc]], especially if you are starting out with [[meds:antipsychotics:first-gen-typical:1-haloperidol|haloperidol]]. | Don't forget to order a baseline ECG for a [[meds:qtc|QTc]], especially if you are starting out with [[meds:antipsychotics:first-gen-typical:1-haloperidol|haloperidol]]. | ||
| </callout> | </callout> | ||
| - | * Antipsychotic medications should not be used as standard treatment for delirium, and should only be considered for patients with delirium experiencing severe agitation or distress. | + | * Antipsychotic medications should not be used as standard treatment for delirium, and should only be considered for patients with delirium experiencing severe agitation or distress.[([[https://www.cmaj.ca/content/195/31/E1038|Reppas-Rindlisbacher, C., Wiesenfeld, L., & Stall, N. M. (2023). Antipsychotic medications for older adults with delirium admitted to hospital. CMAJ, 195(31), E1038-E1039.]])] |
| - | [([[https://www.cmaj.ca/content/195/31/E1038|Reppas-Rindlisbacher, C., Wiesenfeld, L., & Stall, N. M. (2023). Antipsychotic medications for older adults with delirium admitted to hospital. CMAJ, 195(31), E1038-E1039.]])] | + | |
| * Most studies have shown that haloperidol (at doses < 3.5 mg daily), risperidone, and olanzapine are all equally effective in managing delirium. | * Most studies have shown that haloperidol (at doses < 3.5 mg daily), risperidone, and olanzapine are all equally effective in managing delirium. | ||
| * There is no evidence that prophylactic or preventative pharmacologic treatment works.[([[https://jamanetwork.com/journals/jama/article-abstract/2673149?redirect=true|van den Boogaard, M., Slooter, A. J., Brüggemann, R. J., Schoonhoven, L., Beishuizen, A., Vermeijden, J. W., ... & Van der Voort, P. H. (2018). Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial. JAMA, 319(7), 680-690.]])][([[https://www.ncbi.nlm.nih.gov/pubmed/31476766|Oh, E. S., Needham, D. M., Nikooie, R., Wilson, L. M., Zhang, A., Robinson, K. A., & Neufeld, K. J. (2019). Antipsychotics for Preventing Delirium in Hospitalized Adults. Annals of internal medicine, 171(7), 474-484.]])] | * There is no evidence that prophylactic or preventative pharmacologic treatment works.[([[https://jamanetwork.com/journals/jama/article-abstract/2673149?redirect=true|van den Boogaard, M., Slooter, A. J., Brüggemann, R. J., Schoonhoven, L., Beishuizen, A., Vermeijden, J. W., ... & Van der Voort, P. H. (2018). Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial. JAMA, 319(7), 680-690.]])][([[https://www.ncbi.nlm.nih.gov/pubmed/31476766|Oh, E. S., Needham, D. M., Nikooie, R., Wilson, L. M., Zhang, A., Robinson, K. A., & Neufeld, K. J. (2019). Antipsychotics for Preventing Delirium in Hospitalized Adults. Annals of internal medicine, 171(7), 474-484.]])] | ||