- Last edited on July 23, 2020
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+ | ====== Hepatic Encephalopathy ====== | ||
+ | ===== Primer ===== | ||
+ | **Hepatic encephalopathy (HE)** or **Portosystemic Encephalopathy (PSE)** is a neuropsychiatric syndrome that can develop in patients with liver disease. | ||
+ | |||
+ | ==== Symptoms ==== | ||
+ | Cognitive impairment, altered level of consciousness, ataxia. | ||
+ | ==== Investigations ==== | ||
+ | * Ammonia levels | ||
+ | * Abdominal ultrasound | ||
+ | * EEGs (to look for findings of encephalopathy) | ||
+ | |||
+ | ==== Differential Diagnosis ==== | ||
+ | * **[[meds:mood-stabilizers-anticonvulsants:1-valproic-divalproex#hyperammonemic-encephalopathy|Valproate-induced hyperammonemic encephalopathy (VHE)]]** | ||
+ | ===== Resources ===== | ||
+ | ==== Literature ==== | ||
+ | * [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421503/|Ferenci, P. (2017). Hepatic encephalopathy. Gastroenterology report, 5(2), 138-147.]] | ||
+ | * [[https://pubmed.ncbi.nlm.nih.gov/10206828/|Wiltfang, J., Nolte, W., Weissenborn, K., Kornhuber, J., & Rüther, E. (1998). Psychiatric aspects of portal-systemic encephalopathy. Metabolic brain disease, 13(4), 379-389.]] | ||
+ | * [[https://pubmed.ncbi.nlm.nih.gov/24365345/|Weissenborn K. (2014). Portosystemic encephalopathy. Handbook of clinical neurology, 120, 661–674.]] | ||
+ | * [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159236/|Tomiyama, A., Oguro, S., Kato, M., Watanabe, H., Yamazaki, H., Suzuki, T., & Tominaga, S. (2016). Successful embolisation of intrahepatic portosystemic venous shunt using AMPLATZER Vascular Plug II. BJR| case reports, 20160061.]] | ||
+ | * [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484308/|Lee, Y. J., Shin, B. S., Lee, I. H., Ohm, J. Y., Lee, B. S., Ahn, M., & Kim, H. J. (2012). Intrahepatic portosystemic venous shunt: successful embolization using the Amplatzer Vascular Plug II. Korean journal of radiology, 13(6), 827-831.]] | ||