- Last edited on September 7, 2020
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cl:neurosyphilis [on July 27, 2020] |
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==== History ==== | ==== History ==== | ||
Prior to the discovery of //Treponema pallidum// (the spirochete bacterium responsible for syphilis) by Japanese bacteriologist Hideyo Noguchi in 1913, neurosyphilis was termed //general paralysis of the insane// (GPI), and erroneously thought to be caused by characterological flaws.[([[https://www.nature.com/articles/d41586-019-02476-w|Harrington, A. (2019). A tale of two disorders: syphilis, hysteria and the struggle to treat mental illness.]])] The identification of //T. pallidum// followed by the later discovery of penicillin and its use in the treatment of syphilis allowed for a curative treatment for GPI. Prior to this, GPI was fatal and it accounted for up to 30% of the primary diagnoses for patients in psychiatric hospitals.[([[https://pubmed.ncbi.nlm.nih.gov/3276007/|Brandt, A. M. (1988). The syphilis epidemic and its relation to AIDS. Science, 239(4838), 375-380.]])] | Prior to the discovery of //Treponema pallidum// (the spirochete bacterium responsible for syphilis) by Japanese bacteriologist Hideyo Noguchi in 1913, neurosyphilis was termed //general paralysis of the insane// (GPI), and erroneously thought to be caused by characterological flaws.[([[https://www.nature.com/articles/d41586-019-02476-w|Harrington, A. (2019). A tale of two disorders: syphilis, hysteria and the struggle to treat mental illness.]])] The identification of //T. pallidum// followed by the later discovery of penicillin and its use in the treatment of syphilis allowed for a curative treatment for GPI. Prior to this, GPI was fatal and it accounted for up to 30% of the primary diagnoses for patients in psychiatric hospitals.[([[https://pubmed.ncbi.nlm.nih.gov/3276007/|Brandt, A. M. (1988). The syphilis epidemic and its relation to AIDS. Science, 239(4838), 375-380.]])] | ||
- | ===== Diagnosis ===== | + | |
- | * [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636106/|Crozatti, L. L., de Brito, M. H., Lopes, B. N. A., & de Campos, F. P. F. (2015). Atypical behavioral and psychiatric symptoms: neurosyphilis should always be considered. Autopsy & case reports, 5(3), 43.]] | + | |
===== Investigations ===== | ===== Investigations ===== | ||
<WRAP group> | <WRAP group> |