https://www.psychdb.com/ 2026-07-30T01:57:29-0700 https://www.psychdb.com/ https://www.psychdb.com/lib/tpl/bootstrap3/images/favicon.ico text/html 2024-11-07T12:57:03-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antidepressants/glaucoma?rev=1731013023&do=diff Antidepressants and Glaucoma Risk Primer The relationship between antidepressant use and glaucoma has been raised as a possible risk in certain populations, though remains under-investigated with sometimes conflicting findings. Glaucoma * Most cases of pre-existing glaucoma is almost always text/html 2024-01-11T11:20:42-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antidepressants/home?rev=1705000842&do=diff Introduction to Antidepressants Primer Antidepressants are a class of medications used primarily in the treatment of mood disorders (e.g. - major depressive disorder) and anxiety disorders. Its use has expanded to neurodegenerative and neuropsychiatric disorders in recent years. History * The development and history of antidepressants began in the 1950s, with the clinical use of two antidepressant drugs: iproniazid (a <ul id="frontpage "style="column-width:20em; -webkit-column-count: 1; -m… text/html 2021-05-17T08:02:32-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antidepressants/serotonin?rev=1621263752&do=diff Serotonin Syndrome Primer Serotonin syndrome (SS) is a clinical triad of mental status changes, autonomic hyperactivity, and neuromuscular changes (hyperreflexia and clonus) due to excess serotonin. Patient's symptoms can vary significantly, from mild symptoms such as tremor and diarrhea to delirium, neuromuscular rigidity, and hyperthermia in life-threatening cases. text/html 2024-02-13T14:31:43-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antidepressants/sexual-dysfunction?rev=1707863503&do=diff Antidepressant-induced Sexual Dysfunction Primer Antidepressant-induced Sexual Dysfunctions are a very common side effect that is often under-recognized, and for some individuals can be protracted even after antidepressant discontinuation. There are unfortunately few well-designed studies to address this problem, and there are also high placebo-response rates for treatments. text/html 2026-01-03T15:16:46-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antidepressants/ssri-withdrawal-discontinuation?rev=1767482206&do=diff Antidepressant Withdrawal (Discontinuation) Syndrome Primer Antidepressant Withdrawal (Discontinuation) Syndrome is a clinically important phenomenon to monitor for. Different antidepressants will have different discontinuation side effects.Shelton, R. C. (2001). Steps following attainment of remission: discontinuation of antidepressant therapy. Primary care companion to the Journal of clinical psychiatry, 3(4), 168. Psychiatric symptoms of discontinuation such as anxiety and agitation, crying… text/html 2024-11-06T11:22:38-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antidepressants/ssris-bleeding?rev=1730920958&do=diff SSRI and SNRI Bleeding Risks Primer Bleeding risks (e.g. - GI bleeding and intracranial bleeding) are associated with selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) in individuals with risk factors. Mechanism The increased risk is thought to be due to the effect of SSRIs inhibiting serotonin uptake in platelets. text/html 2024-02-01T16:22:54-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antidepressants/tapering-switching?rev=1706833374&do=diff Tapering/Switching Antidepressants Primer When a patient does not respond to an initial antidepressant, there are several switching strategies that can be used. Alternatively, if a diagnostic clarification is needed and a patient does not respond on an antidepressant, tapering should also be considered. Choosing the right strategy depends on patient preference, antidepressant profile, and patient response/side effects: