https://www.psychdb.com/ 2026-07-18T01:18:40-0700 https://www.psychdb.com/ https://www.psychdb.com/lib/tpl/bootstrap3/images/favicon.ico text/html 2024-01-21T15:39:54-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antipsychotics/0-long-acting-injectables?rev=1705880394&do=diff Long-Acting Injectable Antipsychotics (LAIs) Primer Long-Acting Injectable (LAI) Antipsychotics are antipsychotics delivered via intramuscular injection that can provide medication coverage from a period of weeks to months. Once stabilized on an LAI, patients rarely will need oral antipsychotic supplementation. text/html 2021-02-24T22:04:19-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antipsychotics/constipation?rev=1614233059&do=diff Antipsychotic‐related Constipation Primer Antipsychotic‐related Constipation is a common and a potentially serious side-effect from antipsychotic use, but has received little attention in recent literature. It is particularly relevant in individuals on text/html 2021-03-02T16:40:15-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antipsychotics/dopamine-supersensitivity-psychosis-dsp?rev=1614732015&do=diff Neuroleptic-Induced Dopamine Supersensitivity Psychosis (DSP) Primer Neuroleptic-Induced Dopamine Supersensitivity Psychosis (DSP) was a concept first introduced by psychiatrist Guy Chouinard in 1980.Chouinard, G., & Jones, B. D. (1980). Neuroleptic-induced supersensitivity psychosis: clinical and pharmacologic characteristics. Am J Psychiatry, 137(1), 16-21. Hypothesis * The hypothesis is that chronic antipsychotic use leads to the upregulation of dopamine (D2) receptors in the basal gang… text/html 2026-06-07T22:28:14-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antipsychotics/eps?rev=1780896494&do=diff Extrapyramidal Symptoms (EPS) Primer Extrapyramidal Symptoms (EPS) are drug-induced movement disorders that occur due to antipsychotic blockade of the nigrostriatal dopamine tracts. These blockades can lead to increased cholinergic activity, resulting in acute dystonia, acute akathisia, antipsychotic-induced parkinsonism, tardive dyskinesia (TD), tardive dystonia, and tardive akathisia. text/html 2024-08-06T15:05:01-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antipsychotics/home?rev=1722981901&do=diff Introduction to Antipsychotics Primer Antipsychotics (also known as neuroleptics or major tranquilizers) are a class of medications mainly used in the treatment of psychosis in schizophrenia and psychosis/mania in bipolar disorder. Its use has expanded to neurodevelopmental, neurodegenerative, and neuropsychiatric disorders in recent years.<ul id="frontpage "style="column-width:20em; -webkit-column-count: 1; -moz-column-count: 1; column-count: 1;" class="catlist_columns catlist-nslist" ><ul id… text/html 2025-04-15T12:07:51-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antipsychotics/hyperprolactinemia?rev=1744744071&do=diff Hyperprolactinemia Primer Hyperprolactinemia is a side effect most commonly associated with antipsychotic use. Hyperprolactinemia can be completely asymptomatic or be very distressing to patients when they experience associated symptoms such as amenorrhea, galactorrhea, infertility, or sexual dysfunction. The most significant consequence of hyperprolactinemia is hypogonadism that results in estrogen or testosterone deficiency. Elevation of prolactin levels can occur as soon as 6 days after ini… text/html 2024-04-16T14:33:45-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antipsychotics/metabolic-syndrome?rev=1713303225&do=diff Metabolic Syndrome Primer Metabolic Syndrome is a group of conditions (including increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels) that occur together. This increases the risk of heart disease, stroke and diabetes. Of psychotropic medications, the risk is greatest with text/html 2024-02-01T18:36:17-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antipsychotics/nms-neuroleptic-malignant-syndrome?rev=1706841377&do=diff Neuroleptic Malignant Syndrome (NMS) Primer Neuroleptic Malignant Syndrome (NMS) is a life-threatening idiosyncratic reaction to dopamine antagonists (most commonly, but not always, antipsychotics) characterized by fever, altered mental status, muscle rigidity, and autonomic dysfunction. text/html 2023-10-10T13:52:42-0700 Anonymous (anonymous@undisclosed.example.com) https://www.psychdb.com/meds/antipsychotics/tapering-switching?rev=1696971162&do=diff Tapering/Switching Antipsychotics Primer Antipsychotics may be tapered or switched due to clinical reasons. There are no published controlled trials on switching antipsychotics, guidelines therefore are only an aid and not necessarily supported by evidence. The risk of antipsychotic discontinuation is significant in primary psychotic disorders (See: