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Primer

Varenicline (Tradename: Champix) is a partial nicotine receptor agonist and antagonist, used for smoking cessation.

Mechanism of Action

	*  Varenicline is a partial agonist and antagonist at the alpha-4 beta-2 nicotinic receptor (α4β2 or a4b2) nicotinic acetylcholine receptor (nAChR)</description>
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