- Last edited on January 23, 2024
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geri:dementia:frontotemporal [on October 21, 2023] psychdb [Treatment] |
geri:dementia:frontotemporal [on January 23, 2024] psychdb [Primer] |
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| {{INLINETOC}} | {{INLINETOC}} | ||
| ===== Primer ===== | ===== Primer ===== | ||
| - | **Frontotemporal dementia (FTD)**, also known as **frontotemporal lobar degeneration (FTLD)**, or less commonly, Pick's disease, is the most common causes of dementia in adults younger than 60 years. FTD is actually an umbrella clinical term that encompasses a group of neurodegenerative diseases (behavioural-variant frontotemporal dementia, non-fluent variant [[geri:dementia:primary-progressive-aphasia-ppa|primary progressive aphasia]], and semantic-variant [[geri:dementia:primary-progressive-aphasia-ppa|primary progressive aphasia]]). Individuals with behavioural variant may have disinhibited behavior, hyperorality, lack of empathy, impaired executive function, and lack of sympathy; Loss of insight is one of the core features of the frontal/behavioural variant frontotemporal dementia (FTD). Those with primary progressive aphasia will have progressive deficits in speech, grammar, word output, semantic knowledge, or naming. | + | **Frontotemporal dementia (FTD)**, also known as **frontotemporal lobar degeneration (FTLD)**, or less commonly, Pick's disease, is one of the most common causes of dementia in adults younger than 60 years. FTD is actually an umbrella clinical term that encompasses a group of neurodegenerative diseases (behavioural-variant frontotemporal dementia, non-fluent variant [[geri:dementia:primary-progressive-aphasia-ppa|primary progressive aphasia]], and semantic-variant [[geri:dementia:primary-progressive-aphasia-ppa|primary progressive aphasia]]). Individuals with behavioural variant may have disinhibited behavior, hyperorality, lack of empathy, impaired executive function, and lack of sympathy; Loss of insight is one of the core features of the frontal/behavioural variant frontotemporal dementia (FTD). Those with primary progressive aphasia will have progressive deficits in speech, grammar, word output, semantic knowledge, or naming. |
| == Epidemiology == | == Epidemiology == | ||
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| == Comorbidity == | == Comorbidity == | ||
| * A high rate of [[psychosis:schizophrenia-scz|late-onset psychosis]] is a characteristic feature of inherited frontotemporal dementia associated with //C9ORF72// mutations, the most common genetic form of the disorder. | * A high rate of [[psychosis:schizophrenia-scz|late-onset psychosis]] is a characteristic feature of inherited frontotemporal dementia associated with //C9ORF72// mutations, the most common genetic form of the disorder. | ||
| - | * //C9ORF72// mutations are also associated with [[psychosis:schizophrenia-scz|schizophrenia]] and [[bipolar:bipolar-i|bipolar disorder]]. | + | * //C9ORF72// mutations are also associated with [[psychosis:schizophrenia-scz|schizophrenia]] and [[bipolar:bipolar-i|bipolar disorder]].[([[https://pubmed.ncbi.nlm.nih.gov/28238272/|Ducharme, S., Bajestan, S., Dickerson, B. C., & Voon, V. (2017). Psychiatric presentations of C9orf72 mutation: what are the diagnostic implications for clinicians?. The Journal of neuropsychiatry and clinical neurosciences, 29(3), 195-205.]])] |
| * There is a substantial overlap of symptoms between Alzheimer’s disease and frontotemporal dementia. | * There is a substantial overlap of symptoms between Alzheimer’s disease and frontotemporal dementia. | ||