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geri:dementia:lewy-body [on April 11, 2019]
 geri:dementia:lewy-body [on April 17, 2019]
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 ===== Treatment ===== ===== Treatment =====
 ==== Pharmacotherapy ==== ==== Pharmacotherapy ====
-<callout type="​danger"​ title="​Typical antipsychotics are contraindicated in LBD" icon="​true">​A severe sensitivity reaction occurs in an estimated 25-50% of LBD patients administered typical antipsychotic drugs (especially haloperidol) in the usual dose range.[([[https://​www.ncbi.nlm.nih.gov/​pmc/​articles/​PMC3913181/​|Boot,​ B. P., McDade, E. M., McGinnis, S. M., & Boeve, B. F. (2013). Treatment of dementia with Lewy bodies. Current treatment options in neurology, 15(6), 738-764.]])] This results in cognitive impairment, sedation, increased/​irreversible acute onset of parkinsonism,​ or symptoms resembling [[meds:side-effects:​nms|neuroleptic malignant syndrome]]. If an antipsychotic must be used, then low potency atypical antipsychotics like clozapine or quetiapine should be used.[([[https://​www.lbda.org/​go/​er|Lewy Body Dementia Association:​ Emergency Room Treatment of Psychosis]])]+<callout type="​danger"​ title="​Typical antipsychotics are contraindicated in LBD" icon="​true">​A severe sensitivity reaction occurs in an estimated 25-50% of LBD patients administered typical antipsychotic drugs (especially haloperidol) in the usual dose range.[([[https://​www.ncbi.nlm.nih.gov/​pmc/​articles/​PMC3913181/​|Boot,​ B. P., McDade, E. M., McGinnis, S. M., & Boeve, B. F. (2013). Treatment of dementia with Lewy bodies. Current treatment options in neurology, 15(6), 738-764.]])] This results in cognitive impairment, sedation, increased/​irreversible acute onset of parkinsonism,​ or symptoms resembling [[meds:antipsychotics:nms-neuroleptic-malignant-syndrome|neuroleptic malignant syndrome]]. If an antipsychotic must be used, then low potency atypical antipsychotics like clozapine or quetiapine should be used.[([[https://​www.lbda.org/​go/​er|Lewy Body Dementia Association:​ Emergency Room Treatment of Psychosis]])]
 </​callout>​ </​callout>​