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--- geri:dementia:primary-progressive-aphasia-ppa [on September 16, 2018]
+++ geri:dementia:primary-progressive-aphasia-ppa [on June 2, 2019]
@@ Line 1: / Line 1: @@
+====== Primary Progressive Aphasia (PPA) ======
+===== Primer =====
+**Primary Progressive Aphasia (PPA)** is a neurological syndrome associated with certain types of dementia. [[geri:dementia:alzheimers|Alzheimer’s Disease]] and [[geri:dementia:frontotemporal|frontotemporal dementia]] are the most common underlying forms of dementia in which PPA occurs. PPA typically begins as gradual, subtle language deficits that progresses to a nearly complete inability to speak.
+==== Variants ====
+There are three variants of PPA:
+  - Semantic (the dominant type and is present in most instances of PPA)
+  - Logopenic (LPA), due to atrophy in the left posterior temporal cortex and inferior parietal lobule
+  - Non-fluent/agrammatic (stumbling for words, grammar is very poor)
+===== Diagnostic Criteria =====
+  * [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059138/|Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. E. E. A., ... & Manes, F. (2011). Classification of primary progressive aphasia and its variants. Neurology, WNL-0b013e31821103e6.]]