- Last edited on January 7, 2022
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meds:1-autonomic-pharmacology:home [on December 13, 2019] |
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| <WRAP half column> | <WRAP half column> | ||
| <panel title="Neurotransmitters and Receptors" no-body="true"> | <panel title="Neurotransmitters and Receptors" no-body="true"> | ||
| - | !^! Neurotransmitter ^ Acetylcholine (ACh) ^ Norepinephrine (NE), Epinephrine (E) ^ | + | ^ Neurotransmitter ^ Acetylcholine (ACh) ^ Norepinephrine (NE), Epinephrine (E) ^ |
| ^ Preganglionic neuron (SNS/PNS) | {{fa>check}} | - | | ^ Preganglionic neuron (SNS/PNS) | {{fa>check}} | - | | ||
| ^ Ganglion (SNS/PNS) | {{fa>check}} | - | | ^ Ganglion (SNS/PNS) | {{fa>check}} | - | | ||
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| <callout type="success" title="Learn this table and you will learn to better care for your patients!" icon="true"></callout> | <callout type="success" title="Learn this table and you will learn to better care for your patients!" icon="true"></callout> | ||
| <panel title="Alpha (α) and Beta (β) Receptor Function and Location" no-body="true"> | <panel title="Alpha (α) and Beta (β) Receptor Function and Location" no-body="true"> | ||
| - | ^ Receptor ^ Function ^ Location ^ Agonist ^ Antagonist ^ | + | ^ Receptor ^ Function ^ Location ^ Agonist ^ Antagonist ^ |
| - | ^ Alpha-1 (α1) | Constriction of smooth muscles | <HTML><ul><li>Blood vessels and skin piloerectors (vasoconstriction and goosebumps)</li><li>Sphincters (bladder, GI)</li><li>Uterus (contraction)</li><li>Eye (constriction of radial muscle, leading to pupillary <b>d</b>ilation (my<b>d</b>riasis)</ul></HTML> | <HTML><ul><li>Epinephrine</li><li>Phenylephrine</li></ul></HTML> | <HTML><ul><li>Prazosin (selective α1 antagonist)</li><li>Tamsulosin (selective α1 antagonist)</li><li>Terazosin (selective α1 antagonist)</li></ul></HTML> | | + | ^ Alpha-1 (α1) | Constriction of smooth muscles | <HTML><ul><li>Blood vessels and skin piloerectors (vasoconstriction and goosebumps)</li><li>Sphincters (bladder, GI)</li><li>Uterus (contraction)</li><li>Eye (constriction of radial muscle, leading to pupillary <b>d</b>ilation (my<b>d</b>riasis)</ul></HTML> | <HTML><ul><li>Epinephrine</li><li>Phenylephrine</li></ul></HTML> | <HTML><ul><li>Prazosin (selective α1 antagonist)</li><li>Tamsulosin (selective α1 antagonist)</li><li>Terazosin (selective α1 antagonist)</li><li>Trazodone</li></ul></HTML> | |
| ^ Alpha-2 (α2) | Inhibition of the sympathetic ganglia (i.e. - decreasing SNS activity) | <HTML><ul><li>Presynaptic ganglionic neurons</li><li>GI tract</li></ul></HTML> | <HTML><ul><li>Clonidine</li><li>Guanfacine</li></ul></HTML> | <HTML><ul><li>Mirtazapine</li></ul></HTML> | | ^ Alpha-2 (α2) | Inhibition of the sympathetic ganglia (i.e. - decreasing SNS activity) | <HTML><ul><li>Presynaptic ganglionic neurons</li><li>GI tract</li></ul></HTML> | <HTML><ul><li>Clonidine</li><li>Guanfacine</li></ul></HTML> | <HTML><ul><li>Mirtazapine</li></ul></HTML> | | ||
| ^ Beta-1 (β1) | Increases cardiac performance, liberation of energy, and conservation of water | <HTML><ul><li>Heart</li><li>Fat cells (lipolysis)</li><li>Kidneys (releases renin to conserve water)</li></ul></HTML> | <HTML><ul><li>Dobutamine (used as a positive inotrope for heart failure and cardiogenic shock)</li></ul></HTML> | <HTML><ul><li>Atenolol</li><li>Bisporolol (selective β1 receptor antagonist)</li><li>Metoporolol (selective β1 receptor antagonist)</li><li>Propranolol (β1- and β2-adrenergic receptor antagonist)</li></ul></HTML> | | ^ Beta-1 (β1) | Increases cardiac performance, liberation of energy, and conservation of water | <HTML><ul><li>Heart</li><li>Fat cells (lipolysis)</li><li>Kidneys (releases renin to conserve water)</li></ul></HTML> | <HTML><ul><li>Dobutamine (used as a positive inotrope for heart failure and cardiogenic shock)</li></ul></HTML> | <HTML><ul><li>Atenolol</li><li>Bisporolol (selective β1 receptor antagonist)</li><li>Metoporolol (selective β1 receptor antagonist)</li><li>Propranolol (β1- and β2-adrenergic receptor antagonist)</li></ul></HTML> | | ||