- Last edited on April 30, 2020
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meds:dopamine-agonists:pramipexole [on December 19, 2019] |
meds:dopamine-agonists:pramipexole [on June 7, 2023] (current) psychdb ↷ Links adapted because of a move operation |
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====== Pramipexole ====== | ====== Pramipexole ====== | ||
+ | {{INLINETOC}} | ||
===== Primer ==== | ===== Primer ==== | ||
- | **Pramipexole** (Tradename: //Mirapex//) is a dopamine agonist used in the treatment of [[geri:parkinsons|]] and [[sleep:parasomnias:rls|restless legs syndrome]]. | + | **Pramipexole** (Tradename: //Mirapex//) is a dopamine agonist used in the treatment of [[geri:parkinsons|]] and [[sleep:movement:rls|restless legs syndrome]]. |
+ | ==== Mechanism of Action ==== | ||
* It is a D2 receptor agonist and also has receptor selectivity for the D3 receptor subtype of the D2 subfamily of receptors. | * It is a D2 receptor agonist and also has receptor selectivity for the D3 receptor subtype of the D2 subfamily of receptors. | ||
+ | |||
==== Side Effects ==== | ==== Side Effects ==== | ||
- | There is the potential to cause compulsive behaviours and sudden sleep attacks.[([[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC116443/|Homann, C. N., Wenzel, K., Suppan, K., Ivanic, G., Kriechbaum, N., Crevenna, R., & Ott, E. (2002). Sleep attacks in patients taking dopamine agonists. Bmj, 324(7352), 1483-1487.]])] | + | * There is the potential to cause compulsive behaviours and sudden sleep attacks.[([[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC116443/|Homann, C. N., Wenzel, K., Suppan, K., Ivanic, G., Kriechbaum, N., Crevenna, R., & Ott, E. (2002). Sleep attacks in patients taking dopamine agonists. Bmj, 324(7352), 1483-1487.]])] |
+ | * Pramipexole has the highest risk for developing impulse control disorders, with an up to 40% incidence.[([[https://pubmed.ncbi.nlm.nih.gov/29925549/|Corvol, J. C., Artaud, F., Cormier-Dequaire, F., Rascol, O., Durif, F., Derkinderen, P., ... & DIGPD Study Group. (2018). Longitudinal analysis of impulse control disorders in Parkinson disease. Neurology, 91(3), e189-e201.]])] | ||
+ | |||
+ | ===== Adverse Events ===== | ||
+ | ==== Impulse-Control Disorders (ICDs) ==== | ||
+ | {{page>geri:parkinsons#impulse-control-disorders-icd&nouser&noheader&nodate&nofooter}} | ||
+ | |||
+ | |||
+ | ===== Resources ===== | ||
+ | * [[https://pubmed.ncbi.nlm.nih.gov/30361297/|Martinez-Castrillo, J. C. (2019). Impulse control disorders in Parkinson’s disease: a hard-turning point. Journal of Neurology, Neurosurgery & Psychiatry, 90(1), 2-2.]] |