Differences

Last edited on September 9, 2020

This shows you the differences between two versions of the page.

--- meds:paradoxical-reactions [on April 30, 2020]
+++ meds:paradoxical-reactions [on June 29, 2020]
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 Risk factors for paradoxical responses include age (pediatric or geriatric), genetic predisposition, history of significant alcohol use, and being given large benzodiazepine doses.
-In pediatrics, the risk of paradoxical responses to benzodiazepines are most associated with age and dose. The younger the individual, the greater the risk of having atypical reactions. Higher doses are also more likely to cause a paradoxical response).[([[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820591/|Kirkpatrick, D., Smith, T., Kerfeld, M., Ramsdell, T., Sadiq, H., & Sharma, A. (2016). Paradoxical reaction to alprazolam in an elderly woman with a history of anxiety, mood disorders, and hypothyroidism. Case reports in psychiatry, 2016.]])][([[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726857/|Shin, Y. H., Kim, M. H., Lee, J. J., Choi, S. J., Gwak, M. S., Lee, A. R., ... & Choi, J. H. (2013). The effect of midazolam dose and age on the paradoxical midazolam reaction in Korean pediatric patients. Korean journal of anesthesiology, 65(1), 9.]])] Other risk factors include individuals with autism, learning disabilities, and neurological disorders.[([[https://www.ncbi.nlm.nih.gov/pubmed/2826308|Marrosu, F., Marrosu, G., Rachel, M. G., & Biggio, G. (1987). Paradoxical reactions elicited by diazepam in children with classic autism. Functional neurology, 2(3), 355-361.]])]
+In pediatrics, the risk of paradoxical responses to benzodiazepines are most associated with age and dose. The younger the individual, the greater the risk of having atypical reactions. Higher doses are also more likely to cause a paradoxical response.[([[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820591/|Kirkpatrick, D., Smith, T., Kerfeld, M., Ramsdell, T., Sadiq, H., & Sharma, A. (2016). Paradoxical reaction to alprazolam in an elderly woman with a history of anxiety, mood disorders, and hypothyroidism. Case reports in psychiatry, 2016.]])][([[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726857/|Shin, Y. H., Kim, M. H., Lee, J. J., Choi, S. J., Gwak, M. S., Lee, A. R., ... & Choi, J. H. (2013). The effect of midazolam dose and age on the paradoxical midazolam reaction in Korean pediatric patients. Korean journal of anesthesiology, 65(1), 9.]])] Other risk factors include individuals with autism, learning disabilities, and neurological disorders.[([[https://www.ncbi.nlm.nih.gov/pubmed/2826308|Marrosu, F., Marrosu, G., Rachel, M. G., & Biggio, G. (1987). Paradoxical reactions elicited by diazepam in children with classic autism. Functional neurology, 2(3), 355-361.]])]
 ===== Management =====