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teaching:childhood-trauma-aces [on March 3, 2024]
psychdb 		teaching:childhood-trauma-aces [on March 3, 2024]
psychdb
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   * The stress-related gene FKBP5 may be implicated in the intergenerational transmission of trauma-related effects in adult offspring, depending on how methylation is altered.[([[https://​www.ncbi.nlm.nih.gov/​pmc/​articles/​PMC6561294/​|Zannas,​ A. S., Jia, M., Hafner, K., Baumert, J., Wiechmann, T., Pape, J. C., ... & Binder, E. B. (2019). Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk. Proceedings of the National Academy of Sciences, 116(23), 11370-11379.]])][([[https://​pubmed.ncbi.nlm.nih.gov/​33255215/​|Misiak,​ B., Karpiński, P., Szmida, E., Grąźlewski,​ T., Jabłoński,​ M., Cyranka, K., ... & Frydecka, D. (2020). Adverse Childhood Experiences and Methylation of the FKBP5 Gene in Patients with Psychotic Disorders. Journal of Clinical Medicine, 9(12), 3792.]])]   * The stress-related gene FKBP5 may be implicated in the intergenerational transmission of trauma-related effects in adult offspring, depending on how methylation is altered.[([[https://​www.ncbi.nlm.nih.gov/​pmc/​articles/​PMC6561294/​|Zannas,​ A. S., Jia, M., Hafner, K., Baumert, J., Wiechmann, T., Pape, J. C., ... & Binder, E. B. (2019). Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk. Proceedings of the National Academy of Sciences, 116(23), 11370-11379.]])][([[https://​pubmed.ncbi.nlm.nih.gov/​33255215/​|Misiak,​ B., Karpiński, P., Szmida, E., Grąźlewski,​ T., Jabłoński,​ M., Cyranka, K., ... & Frydecka, D. (2020). Adverse Childhood Experiences and Methylation of the FKBP5 Gene in Patients with Psychotic Disorders. Journal of Clinical Medicine, 9(12), 3792.]])]
 ===== Prevention ===== ===== Prevention =====
-  * ACEs and their negative outcomes are preventable. However, this requires major societal and institutional involvement in creating and maintaining safe, stable, nurturing relationships and environments for all children and their families.+  * ACEs and their negative outcomes are preventable. ​ 
 +    * However, this requires major societal and institutional involvement in creating and maintaining safe, stable, nurturing relationships and environments for all children and their families.
   * Positive relationships with parents and with nonparental adults during childhood may reduce the risk of later mental disorders regardless of exposure to ACEs.[([[https://​pubmed.ncbi.nlm.nih.gov/​38150238/​|VanBronkhorst,​ S. B., Abraham, E., Dambreville,​ R., Ramos-Olazagasti,​ M. A., Wall, M., Saunders, D. C., ... & Duarte, C. S. (2023). Sociocultural Risk and Resilience in the Context of Adverse Childhood Experiences. JAMA psychiatry.]])]   * Positive relationships with parents and with nonparental adults during childhood may reduce the risk of later mental disorders regardless of exposure to ACEs.[([[https://​pubmed.ncbi.nlm.nih.gov/​38150238/​|VanBronkhorst,​ S. B., Abraham, E., Dambreville,​ R., Ramos-Olazagasti,​ M. A., Wall, M., Saunders, D. C., ... & Duarte, C. S. (2023). Sociocultural Risk and Resilience in the Context of Adverse Childhood Experiences. JAMA psychiatry.]])]
   * Participating in team sports during adolescence may lead to better outcomes in those exposed to ACEs.[([[https://​pubmed.ncbi.nlm.nih.gov/​31135890/​|Easterlin,​ M. C., Chung, P. J., Leng, M., & Dudovitz, R. (2019). Association of team sports participation with long-term mental health outcomes among individuals exposed to adverse childhood experiences. JAMA pediatrics, 173(7), 681-688.]])]   * Participating in team sports during adolescence may lead to better outcomes in those exposed to ACEs.[([[https://​pubmed.ncbi.nlm.nih.gov/​31135890/​|Easterlin,​ M. C., Chung, P. J., Leng, M., & Dudovitz, R. (2019). Association of team sports participation with long-term mental health outcomes among individuals exposed to adverse childhood experiences. JAMA pediatrics, 173(7), 681-688.]])]