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teaching:genetics-psychiatry [on April 30, 2020] |
teaching:genetics-psychiatry [on July 9, 2020] |
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===== Primer ===== | ===== Primer ===== | ||
- | Mental disorders are highly heritable. Understanding the genetics behind this can lead to better patient care. | + | **Psychiatric Genetics** is the study of the role of genetics in the development of mental disorders. Many mental disorders are highly heritable. |
- | + | ||
- | ===== Serotonin Transporter Gene and Depression (5-HTTLPR) ===== | + | |
- | * [[https://www.ncbi.nlm.nih.gov/pubmed/30845820|Border, R., Johnson, E. C., Evans, L. M., Smolen, A., Berley, N., Sullivan, P. F., & Keller, M. C. (2019). No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. American Journal of Psychiatry, appi-ajp.]] | + | |
- | * [[https://slatestarcodex.com/2019/05/07/5-httlpr-a-pointed-review/|5-HTTLPR: A Pointed Review]] | + | |
- | * [[https://www.theatlantic.com/science/archive/2019/05/waste-1000-studies/589684/|The Atlantic: A Waste of 1,000 Research Papers]] | + | |
===== Mitochondrial Diseases ===== | ===== Mitochondrial Diseases ===== | ||
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===== DiGeorge (22q11.2) Deletion Syndrome ===== | ===== DiGeorge (22q11.2) Deletion Syndrome ===== | ||
- | <callout type="success">{{fa>arrow-circle-right?color=green}} See main article: **[[child:genetic-disorders:digeorge-syndrome-22q11.2-22q-deletion|]]**</callout> | + | <alert icon="fa fa-arrow-circle-right fa-lg fa-fw" type="success">See main article: **[[child:genetic-disorders:digeorge-syndrome-22q11.2-22q-deletion|]]**</alert> |
===== Risk Genes ===== | ===== Risk Genes ===== | ||
* [[http://www.sciencedirect.com/science/article/pii/S0140673612621291|Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet. 2013;381(9875):1371-1379.]] | * [[http://www.sciencedirect.com/science/article/pii/S0140673612621291|Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet. 2013;381(9875):1371-1379.]] | ||
+ | |||
+ | ===== Serotonin Transporter Gene and Depression (5-HTTLPR) ===== | ||
+ | * [[https://www.ncbi.nlm.nih.gov/pubmed/30845820|Border, R., Johnson, E. C., Evans, L. M., Smolen, A., Berley, N., Sullivan, P. F., & Keller, M. C. (2019). No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. American Journal of Psychiatry, appi-ajp.]] | ||
+ | * [[https://slatestarcodex.com/2019/05/07/5-httlpr-a-pointed-review/|SlateStarCodex: 5-HTTLPR: A Pointed Review]] | ||
+ | * [[https://www.theatlantic.com/science/archive/2019/05/waste-1000-studies/589684/|The Atlantic: A Waste of 1,000 Research Papers]] | ||
+ | * [[https://eiko-fried.com/the-replication-crisis-hits-psychiatry-no-candidate-genes-for-depression/|The replication crisis hits psychiatry: No candidate genes for depression]] | ||
===== Pharmacogenetic Testing ===== | ===== Pharmacogenetic Testing ===== |