Psychiatric Genetics

Mental disorders are highly heritable. Understanding the genetics behind this can lead to better patient care.

• Border, R., Johnson, E. C., Evans, L. M., Smolen, A., Berley, N., Sullivan, P. F., & Keller, M. C. (2019). No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. American Journal of Psychiatry, appi-ajp.
• 5-HTTLPR: A Pointed Review
• The Atlantic: A Waste of 1,000 Research Papers

• Farkas, G. I. (2016). Psychiatric Implications of Mitochondrial Disorders. American Journal of Psychiatry Residents' Journal, 11(07), 8-10.
• Psychotropics, including typical and atypical antipsychotics, selective serotonin reuptake inhibitors, and antiepileptics, interfere with important mitochondrial functions and may worsen symptoms.

• Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet. 2013;381(9875):1371-1379.