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--- teaching:psychobiotics-probiotics [on April 30, 2020]
+++ teaching:psychobiotics-probiotics [on January 4, 2022] (current)
@@ Line 2: / Line 2: @@
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 ===== Primer =====
-**Psychobiotics** is a relatively new and emerging field of psychiatry.
+**Psychobiotics** is a relatively new and emerging field of psychiatry. The body's microbiome plays important roles in inflammatory response and neurologic function.
+===== Mania =====
+  * Certain individuals with acute mania have been found to have elevated levels of inflammation, suggesting a possible role for probiotic use.
+  * A small study demonstrated that the use of supplementation psychobiotics (//Lactobacillus rhamnosus strain GG// and //Bifidobacterium animalis subsp. lactis strain Bb12//) was associated with a lower rate of rehospitalization in patients who have been recently discharged following hospitalization for mania.[([[https://pubmed.ncbi.nlm.nih.gov/29693757/|Dickerson, F., Adamos, M., Katsafanas, E., Khushalani, S., Origoni, A., Savage, C., ... & Yolken, R. H. (2018). Adjunctive probiotic microorganisms to prevent rehospitalization in patients with acute mania: a randomized controlled trial. Bipolar disorders, 20(7), 614-621.]])]
+    * The effects are hypothesized to be due to modulation of central nervous system inflammation through the gut–brain axis.
 ===== Resources =====
 <WRAP group>