Treatment with Z-drugs usually should not exceed 7 to 10 consecutive days.
If there is use for more than 2 to 3 consecutive weeks, the clinician should do a complete re-evaluation of the patient and reassess any underlying medical or psychiatric disorders.
Mechanism of Action
Bind to GABA receptors that are distinct from those affected by benzodiazepines
Advantages
Compared to benzodiazepines, there is minimal anticonvulsant, respiratory depressant, and muscle relaxant effects
Adverse Events
Addiction
These drugs still have addictive potential
Some studies suggest that withdrawal and tolerance can occur after a longer period of use (2 to 3 months) relative to benzodiazepines (4 weeks)