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teaching:genetics-psychiatry [2020/04/30 22:12]
127.0.0.1 external edit
teaching:genetics-psychiatry [2020/07/09 17:07] (current)
psychdb [DiGeorge (22q11.2) Deletion Syndrome]
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 {{INLINETOC}} {{INLINETOC}}
 ===== Primer ===== ===== Primer =====
-Mental ​disorders are highly heritable. ​Understanding the genetics behind this can lead to better patient care. +**Psychiatric Genetics** is the study of the role of genetics in the development of mental disorders. Many mental ​disorders are highly heritable.
- +
-===== Serotonin Transporter Gene and Depression (5-HTTLPR) ===== +
-  * [[https://​www.ncbi.nlm.nih.gov/​pubmed/​30845820|Border,​ R., Johnson, E. C., Evans, L. M., Smolen, A., Berley, N., Sullivan, P. F., & Keller, M. C. (2019). No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. American Journal of Psychiatry, appi-ajp.]] +
-  * [[https://​slatestarcodex.com/​2019/​05/​07/​5-httlpr-a-pointed-review/​|5-HTTLPR:​ A Pointed Review]] +
-  * [[https://​www.theatlantic.com/​science/​archive/​2019/​05/​waste-1000-studies/​589684/​|The Atlantic: A Waste of 1,000 Research Papers]] +
  
 ===== Mitochondrial Diseases ===== ===== Mitochondrial Diseases =====
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 ===== DiGeorge (22q11.2) Deletion Syndrome ===== ===== DiGeorge (22q11.2) Deletion Syndrome =====
-<callout type="success">​{{fa>arrow-circle-right?color=green}} ​See main article: **[[child:​genetic-disorders:​digeorge-syndrome-22q11.2-22q-deletion|]]**</​callout>+<alert icon="​fa ​fa-arrow-circle-right ​fa-lg fa-fw" type="​success">​See main article: **[[child:​genetic-disorders:​digeorge-syndrome-22q11.2-22q-deletion|]]**</​alert>
 ===== Risk Genes ===== ===== Risk Genes =====
   * [[http://​www.sciencedirect.com/​science/​article/​pii/​S0140673612621291|Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet. 2013;​381(9875):​1371-1379.]]   * [[http://​www.sciencedirect.com/​science/​article/​pii/​S0140673612621291|Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet. 2013;​381(9875):​1371-1379.]]
 +
 +===== Serotonin Transporter Gene and Depression (5-HTTLPR) =====
 +  * [[https://​www.ncbi.nlm.nih.gov/​pubmed/​30845820|Border,​ R., Johnson, E. C., Evans, L. M., Smolen, A., Berley, N., Sullivan, P. F., & Keller, M. C. (2019). No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. American Journal of Psychiatry, appi-ajp.]]
 +  * [[https://​slatestarcodex.com/​2019/​05/​07/​5-httlpr-a-pointed-review/​|SlateStarCodex:​ 5-HTTLPR: A Pointed Review]]
 +  * [[https://​www.theatlantic.com/​science/​archive/​2019/​05/​waste-1000-studies/​589684/​|The Atlantic: A Waste of 1,000 Research Papers]]
 +  * [[https://​eiko-fried.com/​the-replication-crisis-hits-psychiatry-no-candidate-genes-for-depression/​|The replication crisis hits psychiatry: No candidate genes for depression]]
  
 ===== Pharmacogenetic Testing ===== ===== Pharmacogenetic Testing =====