Last edited on April 30, 2020 This is an old revision of the document! Psychiatric Side Effects of Medications and Substances Primer Medications and recreational substances can have profound psychiatric symptoms for patients. Medications with Depression as a Side Effect Tango, R. C. (2003). Psychiatric side effects of medications prescribed in internal medicine. Dialogues in clinical neuroscience, 5(2), 155. Qato, D. M., Ozenberger, K., & Olfson, M. (2018). Prevalence of Prescription Medications With Depression as a Potential Adverse Effect Among Adults in the United States. JAMA, 319(22), 2289-2298.