Differences

Last edited on April 30, 2020

This shows you the differences between two versions of the page.

--- mood:1-depression:psychotic [on April 30, 2020]
+++ mood:1-depression:psychotic [on January 26, 2022] (current)
psychdb [Treatment]
@@ Line 2: / Line 2: @@
 {{INLINETOC}}
 ===== Primer =====
-**Psychotic Depression** (depression with psychotic features) requires the treatment of the underlying mood disorder.
+**Psychotic Depression** (also known as **Major Depressive Disorder with psychotic features** in the DSM-5) is a subtype of [[mood:1-depression:home|depression]] characterized by psychosis (delusions, hallucinations) in addition to mood changes. It requires the treatment of the underlying mood disorder first to resolve the psychosis.
-===== Differential Diagnosis =====
-  * [[https://www.ncbi.nlm.nih.gov/pubmed/28709381|Perera, J. K., Rosenblat, J. D., & Flint, A. J. (2017). Dementia with Lewy bodies presenting as psychotic depression. Australian & New Zealand Journal of Psychiatry, 51(11), 1160-1161.]]
 ===== Treatment =====
-Treatment with olanzapine plus sertraline has been shown to be efficacious.[([[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840400/|Meyers, B. S., Flint, A. J., Rothschild, A. J., Mulsant, B. H., Whyte, E. M., Peasley-Miklus, C., ... & Heo, M. (2009). A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD). Archives of general psychiatry, 66(8), 838-847.]])]
+<alert type="info" icon="fa fa-book fa-lg fa-fw">
+See also:
+  * **[[https://www.ncbi.nlm.nih.gov/pubmed/28445632|Bingham et al. (2017). The Association of Baseline Suicidality With Treatment Outcome in Psychotic Depression. The Journal of clinical psychiatry, 78(8), 1149-1154.]]**
+  * **[[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686458/|Rothschild, A. J. (2013). Challenges in the treatment of major depressive disorder with psychotic features. Schizophrenia bulletin, 39(4), 787-796.]]**
+</alert>
-  * [[https://www.ncbi.nlm.nih.gov/pubmed/28445632|Bingham, K. S., Rothschild, A. J., Mulsant, B. H., Whyte, E. M., Meyers, B. S., Banerjee, S., ... & Flint, A. J. (2017). The Association of Baseline Suicidality With Treatment Outcome in Psychotic Depression. The Journal of clinical psychiatry, 78(8), 1149-1154.]]
+  * For psychotic depression, treatment with an antidepressant-antipsychotic combination is better than treating with an antidepressant or antipsychotic alone.[([[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994790/|Kennedy, S. H., Lam, R. W., McIntyre, R. S., Tourjman, S. V., Bhat, V., Blier, P., ... & CANMAT Depression Work Group. (2016). Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 3. Pharmacological treatments. The Canadian Journal of Psychiatry, 61(9), 540-560.]])] For example, treatment with olanzapine plus sertraline has been shown to be efficacious.[([[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840400/|Meyers, B. S., Flint, A. J., Rothschild, A. J., Mulsant, B. H., Whyte, E. M., Peasley-Miklus, C., ... & Heo, M. (2009). A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD). Archives of general psychiatry, 66(8), 838-847.]])] It remains uncertain how long one should remain on this combination treatment once the psychotic depressive episode has remitted.
-  * [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686458/|Rothschild, A. J. (2013). Challenges in the treatment of major depressive disorder with psychotic features. Schizophrenia bulletin, 39(4), 787-796.]]
+===== Resources =====
+  * [[https://www.ncbi.nlm.nih.gov/pubmed/28709381|Perera, J. K., Rosenblat, J. D., & Flint, A. J. (2017). Dementia with Lewy bodies presenting as psychotic depression. Australian & New Zealand Journal of Psychiatry, 51(11), 1160-1161.]]