Psychotic Depression

Psychotic Depression (also known as Major Depressive Disorder with psychotic features in the DSM-5) is a subtype of depression characterized by psychosis (delusions, hallucinations) in addition to mood changes. It requires the treatment of the underlying mood disorder first to resolve the psychosis.

For psychotic depression, treatment with an antidepressant-antipsychotic combination than treating with an antidepressant or antipsychotic alone.[1] For example, treatment with olanzapine plus sertraline has been shown to be efficacious.[2] It remains uncertain how long one should remain on this combination treatment once the psychotic depressive episode has remitted.