Psychotic Depression

Psychotic Depression (also known as Major Depressive Disorder with psychotic features in the DSM-5) is a subtype of depression characterized by psychosis (delusions, hallucinations) in addition to mood changes. It requires the treatment of the underlying mood disorder first to resolve the psychosis.

  • For psychotic depression, treatment with an antidepressant-antipsychotic combination than treating with an antidepressant or antipsychotic alone.[1] For example, treatment with olanzapine plus sertraline has been shown to be efficacious.[2] It remains uncertain how long one should remain on this combination treatment once the psychotic depressive episode has remitted.