Table of Contents
Desipramine (Norpramin)
Primer
Dosing
Pharmacokinetics
Pearls
Desipramine (Norpramin)
Table of Contents
Desipramine (Norpramin)
Primer
Dosing
Pharmacokinetics
Pearls
Primer
Desipramine
(Trade name:
Norpramin
) is a
tricyclic antidepressant
. It is a more activating TCA.
Tricyclic Antidepressants (TCA)
Amitriptyline (Elavil)
Clomipramine (Anafranil)
Desipramine (Norpramin)
Doxepin (Sinequan)
Imipramine (Tofranil)
Nortriptyline (Pamelor/Aventyl)
Dosing
Start at 25mg, can increase up to 100mg. Can be given as a single daily dose or in divided doses.
Pharmacokinetics
Desipramine is a metabolite of imipramine.
Pearls
Desipramine is a relatively selective norepinephrine reuptake inhibitor (NRI), and the most noradrenergic of the tricyclic antidepressants.
[1]
References
1)
Gillman, P. K. (2007). Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. British journal of pharmacology, 151(6), 737-748.