- Last edited on February 9, 2022
Doxepin (Sinequan)
Primer
Doxepin (Trade name: Sinequan, Silenor) is a tricyclic antidepressant.
Dosing
- Half-life: 3.5 hours
Indications
- Insomnia (middle insomnia, doses of 3 to 6 mg qHS in Canada)[1]
Mechanism
- Doxepin has prominent histaminergic effects, and NO anticholinergic effects, which makes it a relatively safe sleep aid
- Best used for the short-term treatment of maintenance (middle) insomnia, not initial insomnia