Desipramine (Norpramin) - PsychDB

Last edited on May 13, 2021

Table of Contents

Desipramine (Norpramin)
- Primer
- Dosing
  - Pharmacokinetics
- Pearls

Desipramine (Trade name: Norpramin) is a tricyclic antidepressant. It is a more activating TCA.

Start at 25mg, can increase up to 100mg. Can be given as a single daily dose or in divided doses.

Desipramine is a metabolite of imipramine.

Desipramine is a relatively selective norepinephrine reuptake inhibitor (NRI), and the most noradrenergic of the tricyclic antidepressants.^[1]

¹⁾ Gillman, P. K. (2007). Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. British journal of pharmacology, 151(6), 737-748.