Table of Contents

Pitolisant (Wakix)

Primer

Pitolisant (Trade name: Wakix) is a histamine 3 (H3) receptor antagonist/inverse agonist used in the treatment of excessive daytime sleepiness in narcolepsy.

Pharmacokinetics

Pharmacokinetics of Pitolisant

Pitolisant: Cytochrome P450 Metabolism

Substrate of (Metabolized by)
Induces
Inhibits

Pharmacodynamics

Mechanism of Action

Toxicity

Indications

Dosing

Dosing for Pitolisant

Starting
Titration
Maximum
Taper

Formulations

Monitoring

Contraindications

Absolute

Relative

Drug-Drug Interactions

Side Effects

Adverse Events

* QTc prolongation * Neuroleptic malignant syndrome *. Serotonin syndrome

Clinical Pearls

Special Populations

Geriatric

Pediatric

Obstetric and Fetal

Medically Ill

Resources