Neuroleptic Malignant Syndrome (NMS)

Neuroleptic Malignant Syndrome (NMS) is a life-threatening idiosyncratic reaction to antipsychotics characterized by fever, altered mental status, muscle rigidity, and autonomic dysfunction. It is hypothesized to be due to excessive dopamine receptor blockade. Certain individuals may be at a higher risk for NMS.

NMS has similar symptoms as malignant hyperthermia, but are distinctly different conditions with different etiologies.[1][2]

  • Blood work
  • CK, Ca (may go up or down)