Table of Contents

Agomelatine

Agomelatine

Table of Contents

Agomelatine

Primer

Agomelatine is an atypical antidepressant melatonin receptor agonist and a serotonin 5-HT_2C receptor antagonist.

Mnemonic

AgoMELatine is a MELatonin receptor agonist.

Pharmacodynamics

Mechanism of Action

Agomelatine stimulates the melatonin receptors and blocks serotonin receptors.

Adverse Events

Agomelatine may require regular liver function testing due to its potential to elevate liver enzymes (1.3%) and sporadic cases of toxic hepatitis.^[1]

¹⁾ Kennedy, S. H., Lam, R. W., McIntyre, R. S., Tourjman, S. V., Bhat, V., Blier, P., ... & CANMAT Depression Work Group. (2016). Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 3. Pharmacological treatments. The Canadian Journal of Psychiatry, 61(9), 540-560.