Agomelatine is an atypical antidepressant melatonin receptor agonist and a serotonin 5-HT2C receptor antagonist.


AgoMELatine is a MELatonin receptor agonist.

Agomelatine stimulates the melatonin receptors and blocks serotonin receptors.

  • Agomelatine may require regular liver function testing due to its potential to elevate liver enzymes (1.3%) and sporadic cases of toxic hepatitis.[1]