- Last edited on February 21, 2021
Ramelteon (Rozerem)
Primer
Ramelteon (Trade name: Rozerem) is nelatonin receptor agonist use in the treatment of insomnia disorder.
Mnemonic
RaMEL
teon is a MEL
atonin receptor agonist.
Pharmacokinetics
See also article: Introduction to Pharmacology
Pharmacokinetics of Ramelteon
Absorption | |
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Distribution | |
Metabolism | |
Elimination | |
Half-life | 1-2.6 hours |
See also article: Cytochrome (CYP) P450 Metabolism
Ramelteon: Cytochrome P450 Metabolism
Substrate of (Metabolized by) | |
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Induces | |
Inhibits |
Pharmacodynamics
Mechanism of Action
- Melatonin receptor agonist that binds MT1 and MT2 in suprachiasmatic nucleus (SCN).
Toxicity
Indications
Dosing
Dosing for Ramelteon
Starting | |
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Titration | |
Maximum | |
Taper |
Formulations
- Ramelteon comes in
Monitoring
Contraindications
Absolute
Relative
Drug-Drug Interactions
Side Effects
- Dizziness, nausea, fatigue, headache
- No dependence
Adverse Events
Clinical Pearls
Special Populations
Geriatric
See main article: Geriatric Pharmacology
Pediatric
See main article: Pediatric Pharmacology
Obstetric and Fetal
See main article: Obstetric and Fetal Pharmacology
Medically Ill
See main article: Psychotropic Dosing in the Medically Ill