Ramelteon (Rozerem)

Ramelteon (Trade name: Rozerem) is nelatonin receptor agonist use in the treatment of insomnia disorder.

Mnemonic

RaMELteon is a MELatonin receptor agonist.

Pharmacokinetics of Ramelteon

Ramelteon: Cytochrome P450 Metabolism

Substrate of (Metabolized by)
Induces
Inhibits
  • Melatonin receptor agonist that binds MT1 and MT2 in suprachiasmatic nucleus (SCN).

Dosing for Ramelteon

Starting
Titration
Maximum
Taper
  • Ramelteon comes in
  • Dizziness, nausea, fatigue, headache
  • No dependence