- Last edited on February 21, 2021
Ramelteon (Rozerem)
Primer
Ramelteon (Trade name: Rozerem) is nelatonin receptor agonist use in the treatment of insomnia disorder.
Mnemonic
RaMELteon is a MELatonin receptor agonist.
Pharmacokinetics
See also article: Introduction to Pharmacology
Pharmacokinetics of Ramelteon
| Absorption | |
|---|---|
| Distribution | |
| Metabolism | |
| Elimination | |
| Half-life | 1-2.6 hours |
See also article: Cytochrome (CYP) P450 Metabolism
Ramelteon: Cytochrome P450 Metabolism
| Substrate of (Metabolized by) | |
|---|---|
| Induces | |
| Inhibits |
Pharmacodynamics
Mechanism of Action
- Melatonin receptor agonist that binds MT1 and MT2 in suprachiasmatic nucleus (SCN).
Toxicity
Indications
Dosing
Dosing for Ramelteon
| Starting | |
|---|---|
| Titration | |
| Maximum | |
| Taper |
Formulations
- Ramelteon comes in
Monitoring
Contraindications
Absolute
Relative
Drug-Drug Interactions
Side Effects
- Dizziness, nausea, fatigue, headache
- No dependence
Adverse Events
Clinical Pearls
Special Populations
Geriatric
See main article: Geriatric Pharmacology
Pediatric
See main article: Pediatric Pharmacology
Obstetric and Fetal
See main article: Obstetric and Fetal Pharmacology
Medically Ill
See main article: Psychotropic Dosing in the Medically Ill