Psychiatric Manifestations of Paraneoplastic Disorders

Paraneoplastic disorders can lead to severe psychiatric and behavioural symptoms. Rapid identification is required to ensure correct treatment and management.

Paraneoplastic limbic encephalitis (PLE) is a rare neurological syndrome associated with cancer, and selectively affects limbic system structures, including the hippocampus, hypothalamus, and amygdala.[1] It is usually associated with small cell lung cancer. The encephalitis is caused by an altered immunologic response to a malignancy that has antigens that resemble limbic antigens. The inflammatory response, however, occurs away from the original neoplasm site. [2]