- Last edited on November 6, 2020
Limbic-predominant Age-related TDP-43 Encephalopathy (LATE)
Primer
Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a proposed neurodegenerative disorder of older adults (typically >80 years old). It presents primarily as an amnestic dementia and is thought to be due to a TDP-43 proteinopathy in limbic system structures, including the hippocampus.
Epidemiology
Based on population autopsy studies, LATE neuropathologic change may be in 20-50% of individuals older than 80 years old.
Prognosis
Comorbidity
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Diagnostic Criteria
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Specifiers
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