Limbic-predominant Age-related TDP-43 Encephalopathy (LATE)

Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a proposed neurodegenerative disorder of older adults (typically >80 years old). It presents primarily as an amnestic dementia and is thought to be due to a TDP-43 proteinopathy in limbic system structures, including the hippocampus.

  • Based on population autopsy studies, LATE neuropathologic change may be in 20-50% of individuals older than 80 years old.