Neuroleptic-Induced Dopamine Supersensitivity Psychosis (DSP)

Neuroleptic-Induced Dopamine Supersensitivity Psychosis (DSP) was a concept first introduced by psychiatrist Guy Chouinard in 1980.[1]

  • The hypothesis is that chronic antipsychotic use leads to the upregulation of dopamine (D2) receptors in the basal ganglia (and thus, tardive dyskinesia).
  • Further, is it also characterized by tolerance to increasing doses of antipsychotic.
  • Finally, most clinically relevant is the hypothesis that rebound psychosis could occur with a reduction or discontinuation of the antipsychotic (separate from the underlying disease course itself).
  • The idea that neuroleptic-induced dopamine supersensitivity psychosis could be iatrogenic is re-emerging in the research literature. This is a controversial, but clinically relevant concept that requires ongoing research because the clinical impact could be significant.