Naltrexone

  • Naltrexone has been shown to be the most efficacious amongst the available pharmacotherapies for alcohol use disorder, although more recent research is showing less of a difference.[1] Naltrexone may be more effective in individuals with a genetic susceptibility to alcohol use disorders.
  • Current illicit opioid use (as indicated by self-report or a positive urine screen) or buprenorphine-naolxone (Suboxone) or methadone maintenance therapy for the treatment of opioid dependence; currently undergoing opioid withdrawal[2]
  • Acute hepatitis or liver failure
  • Anticipated need for opioid analgesics within the next 7 days
  • History of sensitivity to naltrexone, to structurally similar compounds (e.g., naloxone or nalmefene), or to any inactive ingredients in the tablet