- Last edited on October 13, 2022
Pitolisant (Wakix)
Primer
Pitolisant (Trade name: Wakix) is a histamine 3 (H3) receptor antagonist/inverse agonist used in the treatment of excessive daytime sleepiness in narcolepsy.
Pharmacokinetics
See also article: Introduction to Pharmacology
Pharmacokinetics of Pitolisant
See also article: Cytochrome (CYP) P450 Metabolism
Pitolisant: Cytochrome P450 Metabolism
| Substrate of (Metabolized by) | |
|---|---|
| Induces | |
| Inhibits |
Pharmacodynamics
Mechanism of Action
Toxicity
Indications
Dosing
Dosing for Pitolisant
| Starting | |
|---|---|
| Titration | |
| Maximum | |
| Taper |
Formulations
- Pitolisant comes in
Monitoring
Contraindications
Absolute
Relative
Drug-Drug Interactions
Side Effects
Adverse Events
Clinical Pearls
Special Populations
Geriatric
See main article: Geriatric Pharmacology
Pediatric
See main article: Pediatric Pharmacology
Obstetric and Fetal
See main article: Obstetric and Fetal Pharmacology
Medically Ill
See main article: Psychotropic Dosing in the Medically Ill