Aripiprazole (Trade name: Abilify) is an antipsychotic in the atypical antipsychotic class commonly used in the treatment of schizophrenia and bipolar disorder. It is also used as an adjunctive medication in major depressive disorder.
Absorption | Peak plasma concentrations occurring within 3 to 5 hours. Oral bioavailability is 87%. |
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Distribution | 4.9 L/kg (99% bound to serum proteins, primarily albumin) |
Metabolism | Hepatic |
Elimination | Hepatic (minimal renal) |
Half-life | 75 to 94 hours (long half life!) |
Substrate of (Metabolized by) | 2D6, 3A4 |
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Induces | - |
Inhibits | - |
Starting | 2 mg PO qAM |
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Titration | 2-5 mg increments every 2-3 weeks |
Maximum | 30 mg (though 20 mg is a typical dose) |
Taper |