- Last edited on February 25, 2021
Second-Generation (Atypical) Antipsychotics
Primer
Second-Generation (Atypical) Antipsychotics are a class of antipsychotic medications released in the early late 1990s to 2000s.
Mechanism
Atypical antipsychotics block the action of dopamine (DA) in D2 receptors, and also block serotonin 5-HT2 receptors.
Adverse Events
See main article: Metabolic Syndrome
- Atypical antipsychotics are associated with metabolic syndrome, and is the greatest with use of olanzapine. Risperidone and quetiapine have intermediate effects, while aripiprazole, asenapine lurasidone, and ziprasidone have lower effects (but are not weight-neutral).[1]
Extrapyramidal Symptoms
See main article: Extrapyramidal Symptoms (EPS)
Neuroleptic Malignant Syndrome
See main article: Neuroleptic Malignant Syndrome (NMS)