Lurasidone (Latuda)

Pharmacokinetics of Lurasidone

Lurasidone: Cytochrome P450 Metabolism

Substrate of (Metabolized by)
  • Lurasidone has a combination of dopamine (D2) and serotonin (5-HT2A) antagonism.[1]

Dosing for Lurasidone

Starting The recommended dose is 40-80 mg given once daily, with no titration needed.
Lurasidone must be taken with a meal/food with at least 350 calories (or else its absorption is reduced by 50%).[2]
Titration No titration needed, but can be increased.
Maximum 80mg PO daily (studies have gone up to 120mg with no difference in improvement)
Taper Tapering/Switching Antipsychotics
  • In one monotherapy study, a higher dose range (80 mg to 120 mg per day) did not provide any additional efficacy compared to the lower dose range (20 to 60 mg per day).[3]
  • Lurasidone comes in an oral tablet formulation
  • In patients with bipolar depression, responses to high or low lurasidone doses are linearly related to baseline CRP levels, indicating the role of CRP as a possible biomarker for treatment response.[4]
  • Lurasidone is essentially an “improved” ziprasidone, in that there is no QTc prolongation risk, and also you can do once daily dosing (unlike BID dosing with ziprasidone).