Lurasidone (Latuda)

Pharmacokinetics of Lurasidone

Lurasidone: Cytochrome P450 Metabolism

Substrate of (Metabolized by)
Induces
Inhibits
  • Lurasidone has a combination of dopamine (D2) and serotonin (5-HT2A) antagonism.[1]

Dosing for Lurasidone

Starting The recommended dose is 40-80 mg given once daily, with no titration needed
Titration
Maximum
Taper
  • Lurasidone comes in
  • In patients with bipolar depression, responses to high or low lurasidone doses are linearly related to baseline CRP levels, indicating the role of CRP as a possible biomarker for treatment response.[2]
  • Lurasidone is essentially an “improved” ziprasidone, in that there is no QTc prolongation risk, and also you can do once daily dosing (unlike BID dosing with ziprasidone).