May 2019 By


Sedative-Hypnotic Drugs (also known as depressants) slows down or “depresses” neurotransmission levels, reducing arousal/stimulation in various areas of the brain. Common sedative-hypnotics include barbiturates (e.g. - phenobarbital) and benzodiazepines (e.g. - lorazepam, alprazolam, and diazepam). Other drugs include methaqualone (“Quaaludes”) and meprobamate (Miltown). Alcohol is also a depressant as well.

Drug Profile

Class Benzodiazepine Street Names Benzos, Downers, Tranks, Nerve Pills. Xanax (alprazolam) is commonly called Xannies (or Zannies), bars (referring to the shape of the pill)
Mechanism Potentiates effects of GABA at the GABAA receptor channel. Increases Cl- flow. Street price $5 for 10mg
Psychological Effects Amnesia, anticonvulsant, sedation, relaxation, disinhibition. Withdrawal Symptoms Palpitations, tachycardia
Physical Symptoms Decreased respiration rate, decreased heart rate.
See main article: Tapering Benzodiazepines