Kleine–Levin Syndrome (KLS)

Primer

Kleine–Levin Syndrome (KLS) is a rare neuropsychiatric disorder characterized by persistent episodic hypersomnia, hyperphagia, cognitive impairment, and mood changes. Individuals can also experience hypersexuality, personality changes, and behavioural changes.

Epidemiology
  • The prevalence of KLS is thought to be extremely rare, perhaps 1 in 1 million.
Prognosis
Comorbidity
Risk Factors
  • Adolescent males are at the greatest risk.

Diagnostic Criteria

Signs and Symptoms

Screening and Rating Scales

Pathophysiology

Differential Diagnosis

Investigations

Physical Exam

Treatment

Guidelines

Resources

For Patients
For Providers
Articles
Research